8 Benefits of Nicotinamide

Nicotinamide - Golden Thread of Youth

What is it?
Ncotinamide, (ni-kə-tē-nə-mīd) also known as niacinamide and nicotinic amide, is the amide of nicotinic acid (vitamin B₃ / niacin). Nicotinamide is a water-soluble vitamin and is part of the vitamin B group. Nicotinic acid, also known as niacin, is converted to nicotinamide in vivo, and, though the two are identical in their vitamin functions, nicotinamide does not have the same pharmacological and toxic effects of niacin, the kind of vitamin B3 which does not cause flushing when you take it. It has a stunning ability to reverse many aspect of ageing when used internally as a supplement and externally in skincare products.

Renewing Nicotinamide
1, Increases collagen systhesis by stimulating the activity of fibroblasts.
2, Decreases skin inflammation by inhibiting the release of histadine.
3, Enhances the synthesis of lipids important for healthy cell walls and skin beauty.
4, Diminishes wrinkles.
5, Repairs DNA after skin has been exposed to too much UV light or chemical pollution.
6, Increases the moisture-holding gel in which skin cell are suspended.
7, Fades age spots and help prevent the formation of new ones.
8, Plays a central role in blocking genetic messages which can result in skin cell ageing and death.

Niacinamide, or nicotinamide, is one of two forms of vitamin B3, the other being niacin. Niacinamide is essential for hundreds of enzymatic reactions; research has shown its benefits in arthritis, asthma, diabetes, cardiovascular disease, stress and stroke.
Niacinamide:

• has been recognized for over 50 years for its benefits in the treatment of arthritis. It improves joint mobility and severity of arthritis in general, allowing doses of anti-inflammatory drugs to be lowered;
• in diabetics, delays the destruction of insulin-producing pancreatic cells, prevents cell damage and improves regeneration, reduces levels of glycated haemoglobin and improves parameters of glycaemia. It improves the condition of alcoholics suffering from chronic pancreatitis;
• together with niacin, has been used since 1940 to treat a number of psychiatric diseases, in particular, schizophrenia;
• is used to treat various inflammatory skin conditions and pigmentation disorders;
• reduces the psychological effects of stress and anxiety;
• represents a potentially effective treatment for adolescent behavioural problems;
• helps stabilize the ATP/ADP ratio in the brain, and as a result, energy levels.

Gene therapy research has also increased interest in niacinamide: a gene promoting longevity called Sir2 (silent information regulator 2) produces a protein, Sir2p, which extends the lifespan of cells. It controls the rate of cell ageing by regulating production of genetic ‘waste products' the accumulation of which destroys the cell. This protein is dependent for its activity on the intracellular presence of nicotinamide-adenine-dinucleotide (NAD). Niacinamide supplementation helps to directly increase intracellular NAD levels and thus the activity of the anti-ageing protein Sir2p. Niacinamide is thus emerging as a first-generation tool in anti-ageing gene therapy.
This safe, effective and inexpensive nutrient represents an essential element of your anti-ageing programme.

Journal References:
Kenton, Leslie. Licastro F. Walford R.L